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ICD-10 Guide
ICD-10 CodesR77.1

R77.1

Abnormality of globulin

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R77.1 is a billable code used to indicate a diagnosis of abnormality of globulin.

Key Diagnostic Point:

Abnormality of globulin refers to deviations from normal globulin levels in the blood, which can indicate various underlying health issues. Globulins are a group of proteins in the blood that play critical roles in immune function, transport of substances, and blood clotting. Abnormal levels can be detected through serum protein electrophoresis, which separates proteins based on their size and charge. Common symptoms associated with abnormal globulin levels may include fatigue, weakness, and signs of immune dysfunction. Conditions leading to abnormal globulin levels include liver disease, chronic inflammatory conditions, multiple myeloma, and autoimmune disorders. Clinicians often investigate these abnormalities further through additional laboratory tests and clinical assessments to determine the underlying cause and appropriate treatment. Accurate coding of this condition is essential for proper patient management and reimbursement.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in globulin levels based on age, sex, and hydration status
  • Need for comprehensive lab results interpretation
  • Potential overlap with other conditions affecting protein levels
  • Documentation of clinical context and symptoms

Audit Risk Factors

  • Inadequate documentation of lab results
  • Failure to link symptoms to the abnormal finding
  • Misinterpretation of globulin levels without clinical context
  • Incorrect coding due to overlapping symptoms with other conditions

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed lab results, clinical history, and any associated symptoms must be documented.

Common Clinical Scenarios

Patients presenting with fatigue, unexplained weight loss, or recurrent infections.

Billing Considerations

Consideration of chronic diseases that may affect globulin levels, such as liver disease or autoimmune disorders.

Emergency Medicine

Documentation Requirements

Acute care documentation must include immediate lab results and any interventions taken.

Common Clinical Scenarios

Patients with acute infections or severe dehydration presenting with abnormal lab findings.

Billing Considerations

Rapid assessment of globulin levels in the context of acute illness is crucial.

Coding Guidelines

Inclusion Criteria

Use R77.1 When
  • Follow official ICD
  • CM guidelines for coding symptoms and abnormal findings
  • Ensure that the abnormality is documented clearly and linked to the patient's clinical presentation

Exclusion Criteria

Do NOT use R77.1 When
No specific exclusions found.

Related CPT Codes

84155CPT Code

Protein electrophoresis

Clinical Scenario

Used to evaluate abnormal globulin levels.

Documentation Requirements

Document the reason for the test and any relevant clinical findings.

Specialty Considerations

Internal medicine and hematology often utilize this test for diagnosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of abnormalities, improving the ability to track and manage conditions related to globulin levels.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of abnormalities, improving the ability to track and manage conditions related to globulin levels.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of abnormalities, improving the ability to track and manage conditions related to globulin levels.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What are the common causes of abnormal globulin levels?

Common causes include liver disease, chronic inflammatory conditions, infections, and hematological malignancies such as multiple myeloma.