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ICD-10 Guide
ICD-10 CodesR78.5

R78.5

Finding of other psychotropic drug in blood

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R78.5 is a billable code used to indicate a diagnosis of finding of other psychotropic drug in blood.

Key Diagnostic Point:

R78.5 is used to indicate the presence of psychotropic drugs in the blood that are not classified under more specific codes. Psychotropic drugs include a wide range of medications used to treat mental health disorders, such as antidepressants, antipsychotics, mood stabilizers, and anxiolytics. The detection of these substances in the bloodstream can be indicative of therapeutic use, misuse, or overdose. Symptoms associated with psychotropic drug presence may include altered mental status, sedation, agitation, or other neurological signs depending on the specific drug involved. Laboratory findings may include toxicology screens or specific blood tests that reveal the concentration of these drugs. Accurate coding requires careful documentation of the clinical context, including the reason for testing, the patient's symptoms, and any relevant medical history, to ensure that the findings are appropriately classified and understood in the context of the patient's overall health status.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in psychotropic drug classifications
  • Need for precise documentation of drug type and dosage
  • Differentiation between therapeutic and toxic levels
  • Potential for overlapping symptoms with other conditions

Audit Risk Factors

  • Inadequate documentation of drug type and dosage
  • Failure to specify the clinical context for testing
  • Misclassification of drug presence as a primary diagnosis
  • Inconsistent reporting of symptoms related to drug findings

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Documentation should include the patient's medical history, reason for testing, and any relevant symptoms or signs observed.

Common Clinical Scenarios

Patients presenting with altered mental status or suspected drug interactions.

Billing Considerations

Consideration of polypharmacy and the potential for drug-drug interactions is crucial.

Emergency Medicine

Documentation Requirements

Acute care documentation should detail the patient's presentation, vital signs, and any immediate interventions taken.

Common Clinical Scenarios

Patients presenting with overdose symptoms or severe agitation.

Billing Considerations

Rapid assessment and documentation of the patient's mental status and any life-threatening conditions are essential.

Coding Guidelines

Inclusion Criteria

Use R78.5 When
  • Follow official ICD
  • 10 coding guidelines, ensuring that the code is used in conjunction with appropriate clinical documentation that supports the findings of psychotropic drugs in the blood

Exclusion Criteria

Do NOT use R78.5 When
No specific exclusions found.

Related CPT Codes

80307CPT Code

Drug test, definitive

Clinical Scenario

Used when performing a definitive drug test to identify specific substances in the blood.

Documentation Requirements

Document the reason for testing and the substances tested.

Specialty Considerations

Ensure that the testing aligns with the patient's clinical presentation.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of drug findings, improving the granularity of data for clinical and billing purposes. R78.5 captures a broader category of psychotropic drugs, which may have been less clearly defined in ICD-9.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of drug findings, improving the granularity of data for clinical and billing purposes. R78.5 captures a broader category of psychotropic drugs, which may have been less clearly defined in ICD-9.

Reimbursement & Billing Impact

billing purposes. R78.5 captures a broader category of psychotropic drugs, which may have been less clearly defined in ICD-9.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What should be documented to support the use of R78.5?

Documentation should include the patient's symptoms, the reason for testing, the specific psychotropic drugs involved, and any relevant medical history that supports the findings.