ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesR87.610

R87.610

Atypical squamous cells of undetermined significance on cytologic smear of cervix (ASC-US)

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R87.610 is a billable code used to indicate a diagnosis of atypical squamous cells of undetermined significance on cytologic smear of cervix (asc-us).

Key Diagnostic Point:

Atypical squamous cells of undetermined significance (ASC-US) is a finding on a cervical cytology smear that indicates the presence of abnormal squamous cells that do not meet the criteria for a definitive diagnosis of squamous intraepithelial lesion (SIL). This finding is significant as it may suggest the presence of human papillomavirus (HPV) infection or other underlying conditions, but it does not provide a clear indication of malignancy. ASC-US is often a result of transient HPV infection, which is common in sexually active women. The clinical significance of ASC-US lies in the need for further evaluation, typically through HPV testing or a follow-up Pap smear, to determine the appropriate management. The diagnosis is crucial as it guides the clinician in deciding whether to monitor the patient or to initiate further diagnostic procedures, such as colposcopy. The interpretation of ASC-US requires careful consideration of the patient's history, risk factors, and the context of the cytological findings.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variability in interpretation of cytology results
  • Need for follow-up testing (HPV testing or repeat Pap)
  • Potential for misdiagnosis if clinical context is not considered
  • Documentation of patient history and risk factors

Audit Risk Factors

  • Inadequate documentation of follow-up plans
  • Failure to link ASC-US findings with HPV testing results
  • Misclassification of ASC-US as a higher-grade lesion
  • Lack of patient history regarding sexual health and HPV vaccination

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Documentation should include patient history, risk factors for cervical cancer, and follow-up plans based on cytology results.

Common Clinical Scenarios

Routine screening in women aged 21-65, follow-up after abnormal Pap results.

Billing Considerations

Consideration of patient's HPV vaccination status and sexual history is essential for accurate coding.

Emergency Medicine

Documentation Requirements

Acute care documentation should include the reason for the cytology test and any immediate concerns related to the findings.

Common Clinical Scenarios

Patients presenting with abnormal bleeding or pelvic pain who require urgent evaluation.

Billing Considerations

Emergency settings may require expedited follow-up plans and clear documentation of findings.

Coding Guidelines

Inclusion Criteria

Use R87.610 When
  • According to the official coding guidelines, ASC
  • US should be coded when the cytology report indicates atypical squamous cells without definitive evidence of high
  • grade lesions
  • Follow
  • up recommendations should be documented to support the coding

Exclusion Criteria

Do NOT use R87.610 When
No specific exclusions found.

Related CPT Codes

88141CPT Code

Cytopathology, cervical or vaginal, collected in preservative fluid, automated thin layer preparation

Clinical Scenario

Used when performing a Pap smear that results in ASC-US.

Documentation Requirements

Documentation of the cytology report and follow-up recommendations.

Specialty Considerations

Ensure that the procedure is linked to the diagnosis of ASC-US.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of cervical cytology findings, improving the ability to track and manage abnormal results like ASC-US. This specificity aids in better patient management and research.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of cervical cytology findings, improving the ability to track and manage abnormal results like ASC-US. This specificity aids in better patient management and research.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of cervical cytology findings, improving the ability to track and manage abnormal results like ASC-US. This specificity aids in better patient management and research.

Resources

Clinical References

  • •
    American College of Obstetricians and Gynecologists (ACOG)
  • •
    Centers for Disease Control and Prevention (CDC) - HPV and Cervical Cancer

Coding & Billing References

  • •
    American College of Obstetricians and Gynecologists (ACOG)
  • •
    Centers for Disease Control and Prevention (CDC) - HPV and Cervical Cancer

Frequently Asked Questions

What does ASC-US mean?

ASC-US stands for atypical squamous cells of undetermined significance, indicating abnormal cervical cells that require further evaluation.

How is ASC-US managed?

Management typically involves follow-up HPV testing and repeat Pap smears to determine the need for further intervention.

Is ASC-US a sign of cancer?

ASC-US is not a definitive sign of cancer but indicates the need for further evaluation to rule out high-grade lesions.