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v1.0.0
ICD-10 Guide
ICD-10 CodesR97.1

R97.1

Elevated cancer antigen 125 [CA 125]

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R97.1 is a billable code used to indicate a diagnosis of elevated cancer antigen 125 [ca 125].

Key Diagnostic Point:

Elevated cancer antigen 125 (CA 125) is a biomarker primarily associated with ovarian cancer, although it can also be elevated in other malignancies and benign conditions. CA 125 is a glycoprotein that is often used in clinical practice to monitor treatment response and disease progression in patients with known ovarian cancer. Elevated levels of CA 125 can indicate the presence of malignancy, but they are not specific to cancer and can be influenced by various factors including menstruation, pregnancy, endometriosis, and pelvic inflammatory disease. Clinicians often order CA 125 tests in conjunction with imaging studies and other diagnostic procedures to assess the likelihood of malignancy in patients presenting with abdominal or pelvic symptoms. It is important to interpret CA 125 levels in the context of the patient's clinical picture, as false positives and negatives can occur. Regular monitoring of CA 125 levels can provide valuable information regarding disease status in patients with a history of ovarian cancer.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Non-specificity of CA 125 levels to ovarian cancer
  • Influence of benign conditions on CA 125 levels
  • Need for correlation with clinical findings and imaging
  • Variability in normal ranges based on laboratory standards

Audit Risk Factors

  • Inadequate documentation linking CA 125 levels to specific symptoms or diagnoses
  • Failure to document the clinical rationale for ordering the CA 125 test
  • Misuse of the code in the absence of elevated CA 125 levels
  • Lack of follow-up documentation regarding the patient's clinical status

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Documentation should include the reason for testing, clinical symptoms, and any relevant history of malignancy.

Common Clinical Scenarios

Patients presenting with abdominal pain, bloating, or changes in bowel habits, particularly in those with a family history of ovarian cancer.

Billing Considerations

Consideration of other potential causes for elevated CA 125 levels, such as endometriosis or liver disease, is crucial.

Emergency Medicine

Documentation Requirements

Acute care documentation should detail the patient's presenting symptoms, the decision to order the CA 125 test, and any immediate management steps taken.

Common Clinical Scenarios

Patients presenting with acute abdominal pain or suspected ovarian torsion.

Billing Considerations

Rapid assessment and documentation are essential, as elevated CA 125 may influence urgent surgical decisions.

Coding Guidelines

Inclusion Criteria

Use R97.1 When
  • According to ICD
  • 10 coding guidelines, R97
  • 1 should be used when there is documentation of elevated CA 125 levels without a definitive diagnosis of cancer
  • It is important to ensure that the clinical context supports the use of this code

Exclusion Criteria

Do NOT use R97.1 When
No specific exclusions found.

Related CPT Codes

86300CPT Code

Tumor antigen, CA 125

Clinical Scenario

Used when testing for CA 125 levels in patients with suspected ovarian cancer.

Documentation Requirements

Document the clinical indication for the test and any relevant patient history.

Specialty Considerations

In oncology, ensure that the test results are correlated with treatment plans.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of abnormal lab findings, including elevated CA 125 levels, which can enhance the accuracy of patient records and facilitate better clinical decision-making.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of abnormal lab findings, including elevated CA 125 levels, which can enhance the accuracy of patient records and facilitate better clinical decision-making.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of abnormal lab findings, including elevated CA 125 levels, which can enhance the accuracy of patient records and facilitate better clinical decision-making.

Resources

Clinical References

  • •
    American Cancer Society - CA 125 Test

Coding & Billing References

  • •
    American Cancer Society - CA 125 Test

Frequently Asked Questions

What does an elevated CA 125 level indicate?

An elevated CA 125 level can indicate the presence of ovarian cancer, but it can also be elevated in benign conditions such as endometriosis or pelvic inflammatory disease. It is important to interpret the results in conjunction with clinical findings.