ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesR97.21

R97.21

Rising PSA following treatment for malignant neoplasm of prostate

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R97.21 is a billable code used to indicate a diagnosis of rising psa following treatment for malignant neoplasm of prostate.

Key Diagnostic Point:

Rising PSA (Prostate-Specific Antigen) levels following treatment for malignant neoplasm of the prostate indicate a potential recurrence of prostate cancer or treatment failure. PSA is a protein produced by both normal and malignant cells of the prostate gland, and its levels are monitored post-treatment to assess the effectiveness of interventions such as surgery, radiation, or hormone therapy. A rising PSA level can be a critical sign that warrants further investigation, including imaging studies or biopsy, to determine the presence of residual or recurrent disease. Clinicians must consider the patient's treatment history, the timing of PSA tests, and any accompanying symptoms such as urinary changes or bone pain. It is essential to differentiate between biochemical recurrence and other causes of elevated PSA, such as benign prostatic hyperplasia (BPH) or prostatitis, to guide appropriate management.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Need for precise documentation of treatment history and PSA levels.
  • Differentiation between recurrence and benign causes of elevated PSA.
  • Potential for overlapping symptoms with other prostate conditions.
  • Variability in PSA testing protocols and follow-up timelines.

Audit Risk Factors

  • Inadequate documentation of treatment history.
  • Failure to specify the reason for PSA elevation.
  • Misclassification of PSA levels as normal or abnormal.
  • Lack of follow-up documentation for rising PSA levels.

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Documentation must include the patient's treatment history, PSA levels over time, and any symptoms or findings that may indicate recurrence.

Common Clinical Scenarios

Patients presenting for routine follow-up after prostate cancer treatment with elevated PSA levels.

Billing Considerations

Consideration of comorbid conditions that may affect PSA levels, such as BPH or urinary tract infections.

Emergency Medicine

Documentation Requirements

Acute care documentation should include the patient's presenting symptoms, PSA levels, and any immediate interventions performed.

Common Clinical Scenarios

Patients presenting with acute urinary retention or severe pain with a known history of prostate cancer and rising PSA.

Billing Considerations

Rapid assessment of potential complications related to prostate cancer recurrence, such as bone metastases.

Coding Guidelines

Inclusion Criteria

Use R97.21 When
  • Follow the official ICD
  • CM coding guidelines, ensuring that the code is used in conjunction with appropriate documentation of the patient's treatment history and clinical findings

Exclusion Criteria

Do NOT use R97.21 When
No specific exclusions found.

Related CPT Codes

84153CPT Code

Prostate-specific antigen (PSA) test

Clinical Scenario

Used to monitor PSA levels in patients with a history of prostate cancer.

Documentation Requirements

Document the reason for the PSA test and the patient's treatment history.

Specialty Considerations

Urology and oncology specialties may have specific protocols for PSA monitoring.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of conditions like rising PSA, improving the granularity of data for tracking cancer recurrence and treatment outcomes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of conditions like rising PSA, improving the granularity of data for tracking cancer recurrence and treatment outcomes.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of conditions like rising PSA, improving the granularity of data for tracking cancer recurrence and treatment outcomes.

Resources

Clinical References

  • •
    American Urological Association Guidelines

Coding & Billing References

  • •
    American Urological Association Guidelines

Frequently Asked Questions

What does a rising PSA level indicate?

A rising PSA level following treatment for prostate cancer may indicate a recurrence of the disease or treatment failure, necessitating further evaluation.