ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesR53

R53

Malaise and fatigue

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R53 is a billable code used to indicate a diagnosis of malaise and fatigue.

Key Diagnostic Point:

Malaise and fatigue are non-specific symptoms that can indicate a wide range of underlying health issues. Malaise refers to a general feeling of discomfort or unease, often described as a sense of illness or lack of well-being. Fatigue is characterized by an overwhelming sense of tiredness or lack of energy that is not relieved by rest. These symptoms can arise from various causes, including infections, chronic diseases, psychological conditions, and lifestyle factors. Clinicians often encounter patients presenting with malaise and fatigue as part of a broader clinical picture, necessitating a thorough evaluation to identify the underlying cause. Common causes include viral infections (like influenza), chronic fatigue syndrome, anemia, depression, and metabolic disorders. The diagnostic approach typically involves a detailed patient history, physical examination, and targeted laboratory tests to rule out specific conditions. Given the broad differential diagnosis, it is crucial for healthcare providers to document the context of these symptoms accurately to guide appropriate management and coding.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Non-specific nature of symptoms
  • Wide range of potential underlying causes
  • Need for thorough documentation to support diagnosis
  • Variability in clinical presentation

Audit Risk Factors

  • Inadequate documentation of the underlying cause
  • Misuse of the code for more specific conditions
  • Failure to link symptoms to a definitive diagnosis
  • Overuse in cases where a specific diagnosis can be established

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Detailed patient history, including onset, duration, and associated symptoms.

Common Clinical Scenarios

Patients presenting with unexplained fatigue, often requiring extensive workup.

Billing Considerations

Consideration of chronic conditions that may contribute to malaise and fatigue.

Emergency Medicine

Documentation Requirements

Acute presentation documentation, including vital signs and immediate lab results.

Common Clinical Scenarios

Patients presenting with acute fatigue due to infections or other urgent conditions.

Billing Considerations

Rapid assessment and documentation of potential life-threatening causes.

Coding Guidelines

Inclusion Criteria

Use R53 When
  • According to ICD
  • 10 coding guidelines, R53 should be used when malaise and fatigue are the primary symptoms and no more specific diagnosis is available
  • It is essential to document the context and any associated symptoms to support the use of this code

Exclusion Criteria

Do NOT use R53 When
No specific exclusions found.

Related Codes

Child Codes

7 codes
R53.0
Neoplastic (malignant) related fatigue
R53.1
Weakness
R53.2
Functional quadriplegia
R53.8
Other malaise and fatigue
R53.81
Other malaise
R53.82
Chronic fatigue, unspecified
R53.83
Other fatigue

Related CPT Codes

99213CPT Code

Established patient office visit, Level 3

Clinical Scenario

Used when evaluating a patient presenting with malaise and fatigue.

Documentation Requirements

Document history, examination findings, and medical decision-making.

Specialty Considerations

Internal medicine may require more detailed documentation of chronic conditions.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of symptoms like malaise and fatigue, improving the ability to capture the complexity of patient presentations and facilitating better data analysis.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of symptoms like malaise and fatigue, improving the ability to capture the complexity of patient presentations and facilitating better data analysis.

Reimbursement & Billing Impact

The transition to ICD-10 has allowed for more specific coding of symptoms like malaise and fatigue, improving the ability to capture the complexity of patient presentations and facilitating better data analysis.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

When should I use R53 instead of a more specific code?

Use R53 when malaise and fatigue are the primary symptoms and no specific diagnosis can be established. Ensure thorough documentation to support this coding choice.