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v1.0.0
ICD-10 Guide
DiagnosesLeukopenia

Leukopenia

ICD-10 Coding for Leukopenia(D72.819, D70.1, D72.818)

PRIMARY SPECIALTYOncology
COMPLEXITYHigh
LAST UPDATED09/15/2025
Sam Tuffun, PT, DPT
Physical Therapist | Medical Coding & Billing Contributor

Diagnosis Overview

What is Leukopenia?
Essential facts and insights about Leukopenia

Key Clinical Considerations:

  • Fatigue and weakness
  • Increased susceptibility to infections
  • Key diagnostic tests include complete blood count (CBC) showing low white blood cell count
  • Physical exam may reveal signs of infection or pallor

Clinical Information

Clinical Criteria & Documentation Requirements

  • Document patient's complete blood count results and clinical symptoms
  • Use specific terminology such as 'neutropenia' if applicable
  • Examples include noting the duration of leukopenia and any associated treatments

Coding Guidelines

Usage Guidelines & Examples

  • Follow usage guidelines for coding based on the underlying cause of leukopenia.
  • Common errors include misclassifying leukopenia as a symptom rather than a diagnosis.

Code Exclusions

Important Exclusions

  • Leukopenia due to bone marrow disorders
  • Alternative codes for specific types of leukopenia

Related ICD-10 Codes

Primary Codes
D72.819
Leukopenia, unspecified
D72.810
Neutropenia, unspecified
Ancillary Codes
B34.9
T45.1X5A
Differential Codes
D70.1
D70.1
if leukopenia is due to an infection and documented as such.
D72.819
D72.819
if no specific cause is documented.

Related CPT Codes

CPT codes will be available in a future update.

Specialty Focus

Primary Specialty

Oncology

Specialty Applications

  • Patients undergoing chemotherapy or radiation therapy
  • Oncology clinics and hospitals

Coding Complexity

High Complexity

This diagnosis requires careful attention to:

  • Comprehensive clinical documentation
  • Accurate code selection based on clinical criteria
  • Proper exclusion considerations
  • Specialty-specific coding guidelines

Documentation

Documentation Templates

Billing Information

Billing Considerations

  • Ensure proper documentation for billing
  • Verify code specificity requirements
  • Check for any additional codes needed
  • Review payer-specific guidelines

Common Issues

  • Insufficient clinical documentation
  • Incorrect code selection
  • Missing supporting diagnoses
  • Timing and frequency documentation

Frequently Asked Questions

What are the documentation requirements?

Document the patient's symptoms, lab results, and any treatment plans.

What are the billing considerations?

Ensure accurate coding to reflect the severity and underlying cause of leukopenia.