ICD-10 Logo
ICDxICD-10 Medical Coding
ICD-10 Logo
ICDxICD-10 Medical Coding
ICD 10 CodesDiagnoses
ICD 10 CodesDiagnoses
ICD-10 Logo
ICDxICD-10 Medical Coding

Comprehensive ICD-10-CM code reference with AI-powered search capabilities.

© 2025 ICD Code Compass. All rights reserved.

Browse

  • All Chapters
  • All Categories
  • Diagnoses

Tools

  • AI Code Search
ICD-10-CM codes are maintained by the CDC and CMS. This tool is for reference purposes only.
v1.0.0
ICD-10 Guide
ICD-10 CodesB46

B46

Zygomycosis

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/05/2025

Code Description

ICD-10 B46 is a billable code used to indicate a diagnosis of zygomycosis.

Key Diagnostic Point:

Zygomycosis, also known as mucormycosis, is a severe fungal infection caused by a group of molds called mucormycetes. These fungi are commonly found in soil, decaying fruits, and vegetables. Zygomycosis primarily affects individuals with weakened immune systems, such as those with uncontrolled diabetes, cancer, or those undergoing immunosuppressive therapies. The infection can manifest in various forms, including rhinocerebral, pulmonary, and disseminated zygomycosis. Symptoms may include facial swelling, nasal congestion, fever, cough, and chest pain, depending on the site of infection. Diagnosis is typically made through clinical evaluation, imaging studies, and microbiological cultures. Treatment involves aggressive antifungal therapy, often with amphotericin B, and surgical debridement of necrotic tissue. Early diagnosis and intervention are critical for improving outcomes, especially in immunocompromised patients, where the mortality rate can be significantly high.

Code Complexity Analysis

Complexity Rating: High

High Complexity

Complexity Factors

  • Variety of clinical presentations requiring specific documentation
  • Need for accurate identification of immunocompromised status
  • Potential for co-infections complicating the diagnosis
  • Variability in treatment protocols based on patient condition

Audit Risk Factors

  • Inadequate documentation of immunocompromised status
  • Failure to specify the site of infection
  • Misclassification of the type of fungal infection
  • Lack of supporting clinical evidence for diagnosis

Specialty Focus

Medical Specialties

Infectious Disease

Documentation Requirements

Detailed clinical notes on patient history, immunocompromised status, and treatment response.

Common Clinical Scenarios

Patients presenting with respiratory symptoms and a history of diabetes or recent chemotherapy.

Billing Considerations

Ensure clear documentation of the type of zygomycosis and any comorbid conditions.

Pulmonology

Documentation Requirements

Pulmonary function tests, imaging studies, and detailed symptom descriptions.

Common Clinical Scenarios

Patients with pulmonary zygomycosis presenting with cough and chest pain.

Billing Considerations

Document any prior lung conditions that may complicate the diagnosis.

Coding Guidelines

Inclusion Criteria

Use B46 When
  • Follow the official ICD
  • CM coding guidelines for fungal infections, ensuring accurate documentation of the patient's immunocompromised status and the specific site of infection
  • Include any relevant laboratory results and imaging studies

Exclusion Criteria

Do NOT use B46 When
No specific exclusions found.

Related Codes

Child Codes

8 codes
B46.0
Tinea barbae
B46.1
Tinea unguium
B46.2
Pulmonary mucormycosis
B46.3
Tinea unguium
B46.4
Tinea nigra
B46.5
Candidal endocarditis
B46.8
Other specified zygomycoses
B46.9
Unspecified mycosis, unspecified.

Related CPT Codes

88305CPT Code

Surgical pathology, gross and microscopic examination

Clinical Scenario

Used when surgical debridement is performed for zygomycosis.

Documentation Requirements

Pathology report and clinical notes detailing the procedure.

Specialty Considerations

Ensure that the pathology report clearly indicates the diagnosis of zygomycosis.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of fungal infections, including zygomycosis, improving the accuracy of data collection and reimbursement processes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of fungal infections, including zygomycosis, improving the accuracy of data collection and reimbursement processes.

Reimbursement & Billing Impact

reimbursement processes.

Resources

Clinical References

  • •
    CDC - Fungal Diseases

Coding & Billing References

  • •
    CDC - Fungal Diseases

Frequently Asked Questions

What are the common symptoms of zygomycosis?

Common symptoms include facial swelling, nasal congestion, fever, cough, and chest pain, depending on the site of infection.

How is zygomycosis treated?

Treatment typically involves antifungal medications such as amphotericin B and may require surgical debridement of infected tissue.