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ICD-10 Guide
ICD-10 CodesR74

R74

Abnormal serum enzyme levels

BILLABLE STATUSYes
IMPLEMENTATION DATEOctober 1, 2015
LAST UPDATED09/11/2025

Code Description

ICD-10 R74 is a billable code used to indicate a diagnosis of abnormal serum enzyme levels.

Key Diagnostic Point:

Abnormal serum enzyme levels refer to elevated or decreased levels of specific enzymes in the blood that may indicate underlying health issues. These enzymes, which include liver enzymes (such as AST, ALT, ALP), cardiac enzymes (like troponin), and pancreatic enzymes (like amylase and lipase), play crucial roles in various metabolic processes. Abnormal levels can signal conditions such as liver disease, myocardial infarction, pancreatitis, or muscle disorders. The clinical significance of these findings often depends on the context of the patient's symptoms, medical history, and other laboratory results. For instance, elevated liver enzymes may suggest hepatitis or cirrhosis, while increased cardiac enzymes can indicate heart damage. A thorough diagnostic approach typically involves correlating enzyme levels with clinical symptoms, imaging studies, and possibly further laboratory testing to pinpoint the exact cause of the abnormality. Accurate interpretation of these enzyme levels is essential for effective patient management and treatment planning.

Code Complexity Analysis

Complexity Rating: Medium

Medium Complexity

Complexity Factors

  • Variety of enzymes and their specific clinical implications
  • Need for correlation with clinical symptoms and history
  • Potential for multiple underlying conditions
  • Variability in normal ranges based on demographics and lab standards

Audit Risk Factors

  • Inadequate documentation of clinical rationale for testing
  • Failure to link abnormal enzyme levels to specific diagnoses
  • Misinterpretation of normal vs. abnormal enzyme levels
  • Lack of follow-up documentation for abnormal results

Specialty Focus

Medical Specialties

Internal Medicine

Documentation Requirements

Clear documentation of the patient's symptoms, history, and the clinical rationale for enzyme testing is essential.

Common Clinical Scenarios

Patients presenting with fatigue, jaundice, or abdominal pain may have abnormal liver enzymes.

Billing Considerations

Consideration of medication effects on enzyme levels and the need for repeat testing.

Emergency Medicine

Documentation Requirements

Immediate documentation of presenting symptoms and the urgency of enzyme testing.

Common Clinical Scenarios

Patients with chest pain may require cardiac enzyme testing to rule out myocardial infarction.

Billing Considerations

Rapid interpretation of results is critical in acute settings, and documentation must reflect the urgency.

Coding Guidelines

Inclusion Criteria

Use R74 When
  • Follow official ICD
  • CM guidelines for coding symptoms and abnormal findings
  • Ensure that the code is used in conjunction with a definitive diagnosis when available

Exclusion Criteria

Do NOT use R74 When
No specific exclusions found.

Related Codes

Child Codes

5 codes
R74.0
Nonspecific elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
R74.01
Elevation of levels of liver transaminase levels
R74.02
Elevation of levels of lactic acid dehydrogenase [LDH]
R74.8
Abnormal levels of other serum enzymes
R74.9
Abnormal serum enzyme level, unspecified

Related CPT Codes

84450CPT Code

Liver enzyme panel

Clinical Scenario

Used when evaluating liver function in patients with symptoms of liver disease.

Documentation Requirements

Document the clinical indication for the liver enzyme panel.

Specialty Considerations

Internal medicine may require more detailed documentation compared to emergency settings.

84484CPT Code

Troponin test

Clinical Scenario

Ordered for patients presenting with chest pain to assess for myocardial infarction.

Documentation Requirements

Document the patient's symptoms and clinical findings leading to the test.

Specialty Considerations

Emergency medicine requires rapid documentation and interpretation.

ICD-10 Impact

Diagnostic & Documentation Impact

Enhanced Specificity

ICD-10 Improvements

The transition to ICD-10 has allowed for more specific coding of abnormal enzyme levels, improving the granularity of data for clinical and billing purposes.

ICD-9 vs ICD-10

The transition to ICD-10 has allowed for more specific coding of abnormal enzyme levels, improving the granularity of data for clinical and billing purposes.

Reimbursement & Billing Impact

billing purposes.

Resources

Clinical References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Coding & Billing References

  • •
    ICD-10-CM Official Guidelines for Coding and Reporting

Frequently Asked Questions

What should I document when coding R74?

Document the clinical symptoms, the reason for testing, and any relevant medical history that supports the diagnosis linked to the abnormal enzyme levels.